منابع مشابه
LETTER TO THE EDITOR On the Mechanism of Nitriles Toxicity
This is apropos to some issues raised by Llorens et al. (2009) on our recent publication unraveling the mode of toxicities of acrylonitrile (ACN) and iminodipropionitrile (IDPN) in rats (Khan et al., 2009). In the following text, we have attempted to provide point-wise explanations to the queries of Llorens et al. in the light of relevant literature. The transient behavioral effects appeared af...
متن کاملMeasuring Toxicity in Phase I Clinical Trials--Letter.
We thank Drs. Sharma and Ratain for their commentary (1) on our article regarding toxicity attribution in phase I trials (2). The authors raise important points. First, they observe that we only evaluated studies utilizing single agents, and thus, our findings may not be generalizable to phase I combination trials. Phase I combination trials frequently evaluate multiple dose escalations, and th...
متن کاملPyrimethamine inhibits renal secretion of creatinine.
The mechanism of increased serum creatinine after administration of pyrimethamine and dapsone was evaluated for six healthy volunteers. Serum parameters, urine sediment, and clearances of creatinine, inulin, and para-aminohippurate were assessed prior to and 28 h after the ingestion of a single, combined dose of 100 mg of pyrimethamine and 200 mg of dapsone. In a second series, the same renal f...
متن کاملReply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".
REPLY: In their letter to the editor, in this issue of the American Journal of Physiology-Lung Cellular and Molecular Physiology, Caruso and colleagues (3) reprise longstanding arguments that the tobacco industry uses to cast doubt on evidence linking smoking with disease (7) to question our conclusion that e-cigarettes pose important potential pulmonary risks (4). They argue that we have syste...
متن کاملReply to George Brewer Letter to Jteh Editor (“toxicity of Copper in Drinking Water”)
Ruth Danzeisen1, Bonnie Ransom Stern2, Peter J. Aggett3, Michelle Deveau4, Laura Plunkett5, Andrea Chambers6, Daniel Krewski6, Leonard S. Levy7, Harry J. McArdle8, Carl L. Keen9, Magdalena Araya10, Marc Solioz11 1International Copper Association, New York, New York, USA 2Consulting in Health Sciences and Risk Assessment, BR Stern and Associates, Annandale, Virginia, USA 3Emeritus Professor, Par...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1974
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5896.40-a